Overview
The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleotides and siRNAs.

Summary of Key Responsibilities

• Support non-GMP oligonucleotide production on a tight timeline
• Support purification method development, optimization, and scale-up
• Execute non-GMP oligonucleotide purifications
• Perform downstream processing of purified material
• Conduct in-process analytical tests
• Participate in creating and reviewing SOPs and batch records
• Support campaign activities across other unit operations as needed

Qualifications

• Bachelor’s degree in Chemistry with 1-3 years of laboratory experience, preferably in an industrial setting
• Basic understanding of analytical techniques such as pH, osmolality, conductivity measurement, HPLC, and LC-MS; hands-on experience is preferred
• Knowledge of oligonucleotide manufacturing processes, including phosphoramidite chemistry, chromatography, and ultrafiltration, is a plus
• Experience in record-keeping and strong laboratory documentation practices
• Commitment to high laboratory and scientific standards; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance
• Strong communication skills are essential
• A responsible and proactive individual who can work effectively as part of a team in a highly dynamic environment with aggressive timelines